One of TNWRRC's greatest strengths is its ability to establish and nurture partnerships with a wide range of water-related agencies, individuals, and organizations, including:
- U.S. Geological Survey;
- U.S. Army Corps of Engineers;
- Tennessee Valley Authority;
- Natural Resources Conservation Service;
- Tennessee Department of Environment and Conservation;
- Tennessee Department of Transportation;
- Tennessee Stormwater Association;
- Knox County Department of Engineering;
- Knox County Parks and Recreation Department;
- Ijams Nature Center;
- Water Quality Forum
- Knoxville Utility Board;
- Legacy Parks Foundation;
- University of Memphis;
- Tennessee Technological University;
- University of Tennessee Knoxville